Laboratory “Microbiology and biotechnology of probiotics”

Inventions and rationalization proposals

№FAP 01493 Kutlieva G.J. and Elova N.A. The bioconservant "IMBICON" makes use of local probiotic bacteria. replacements for imported, second-hand conservatives. It is used to prepare a variety of fodder silage and haylage. This bioconservant is essential for the safety and welfare of farm animals.          

FAP № 01679. Kutlieva G.J. and Elova N.A. Probiotic supplement for animal husbandry feed. "Bactovit" is a feed supplement for agriculture and local food production. It was created to ease animal digestion and to substitute antibiotics in feed. Enhancing immunity and safeguarding food safety depend on improved animal health.

IAP 06944. Kutlieva G.J., Kamolova H.F.Turaeva B.I. For usage in agriculture and animal husbandry, the Lactobacillus plantarum strain M-1 exhibits antioxidant and growth-stimulating action as well as activity against opportunistic bacteria and phytopathogenic fungi.

This strain offers potential for the development of potent biologics for use in medicines, animal husbandry, and agriculture. This strain has two active phytohormones, vitamins, and the ability to synthesize amino acids. Biopreparations made from this strain are efficient and safe for the environment.

№ FAP 01512. Kutlieva G.J., Elova N.A. Lactobacilli, yeasts, and spore bacteria can all be grown on an optimal production nutrient media.  This nutritional medium is made from whey, a waste product from the dairy industry. The complex and pricey foreign nutritional media are replaced by it. everything that is now being prepared in the fields of agriculture, animal husbandry, and pharmaceuticals. In the creation of microorganisms, this nutritional medium is frequently employed.

Projects

1. FA-2019-31 "Development of a new biological product for the prevention and treatment of intestinal diseases" 2020-2022.
2. FZ-2020041434 "Development of biopreparation "IMBIOKON" for conservation and preparation of fodder crops" 2020-2021.

      3. Production of prototypes (capsules, sachets) of the dietary supplement "ProbioColite" for the prevention and treatment of inflammatory bowel diseases. 2022-2023.

The bioconservant "IMBICON" is successful in creating high-quality, highly nutrient-dense silage and haylage from a variety of nutrient-dense and coarse fodder crops.

Description of the product

In livestock production, the efficiency of livestock products is directly dependent on the nutritional quality of feed, and the quality of livestock products (milk, fat, meat, etc.) is directly dependent on the nutritional quality of feed. A high-quality, highly nutritious forage should be easily digestible and easily assimilated by animals, have a good taste, and not contain substances that harm animals. When fulfilling these tasks, attention should be paid to quality preparation and processing of forages (forages prepared from different products, silage and silage). The preparation of food products with various probiotic biopreservatives plays a crucial role in ensuring their safety and quality. By using these bioconservatives, dangerous microflora that act as vectors for various diseases can be effectively eliminated. This process not only cleans the food products but also enhances their nutritional value, thereby meeting international standards. Probiotic bioconservatives also guard against mycotoxins, which can produce harmful microflora, and guarantee that feed has vitamins, vital amino acids, and protein. In addition, the balance of beneficial microflora in the digestive system of animals is increased and their activity, milk and meat productivity increase.

Fields of application:

It is used in agriculture and animal husbandry and bioconservation of rough fodder crops grown in arid conditions of desert regions.

Main functional qualities:

• Enhances the quality of silage and haylage;
• Promotes the early ripening of silage and haylage;
• Guards against pathogenic and conditionally pathogenic bacteria in silage and haylage;

Economic efficiency:

Under the effect of the bioconservant, the safety of silage or silage is assured, and the amount lost due to rotting or mold is maintained. There is no comparable to the bioconservant "IMBIOKON". keeps rot and mold at bay. Only foreign nations (Europe) are allowed to introduce bioconservants into our republic. In 2021, IMBIOKON bioconservant was authorized by the State Veterinary Committee. The "IMBIOKON" bioconservant is covered by Uzbekistan's Intellectual Property Agency patent No. FAP 01493.

Biologically active supplement "ProbioKolit" with the properties of prevention and treatment of intestinal inflammatory diseases

Description of the product

Inflammatory bowel illnesses are one of the most urgent issues facing the world today, thus prevention and treatment are crucial. Even if they are covered by social protection by the state, intestinal inflammatory disorders and oncological diseases are becoming more common in our republic. Bowel cancer and other significant problems are brought on by inflammatory bowel illnesses. Therefore, it is necessary to develop and implement measures to prevent and treat such serious diseases. "ProbioKolit" a biologically active supplement with probiotics is safe, highly effective, and has an anti-inflammatory effect. The biologically active supplement "ProbioKolit" has an antimicrobial, restorative, and positive effect on the human immune system. It is recommended for patients to prevent and treat inflammatory bowel diseases.

Fields of application:

Pharmaceuticals and medicine both use it. Both the prevention and therapy of ulcerative colitis involve its usage.

Main functional qualities:

• Improves the functioning of the digestive system;
• Restores a healthy microbial balance in the intestinal system;
• Prevents colds in the digestive system and intestines;
• Prevents and treats ulcerative colitis;

Economic efficiency:

In the USA, a comparative analog is sold for $60-120. The domestic price of the biologically active supplement "ProBioKolit" is cheaper than the price of its imported analog (7 times, 86%). "ProbioKolit" biologically active supplement was registered with the Ministry of Health in 2021 and received a production permit. It is a domestic product that substitutes for imports. It is different from its analogs in the association of probiotic strains.

"ProBioKorm" probiotic feed supplement

Description of the product

Local probiotic nutritional supplements can take the place of different antibiotics that are bad for the body and have an antagonistic impact. Under the active probiotic action, phytopathogenic fungi and bacteria are destroyed. veterinary treatment that eliminates mycotoxins, which are extremely hazardous to animals. It provides the vitamins, amino acids, and proteins that animals require. enhances the nutritional value of food by adding synthetic biologically active ingredients. increases animal immunity, boosts immune system function, enhances digestion, and nourishes the gastrointestinal tract with beneficial microorganisms.

Animal productivity rises as a result. A novel form of multi-component feed additive called "ProBioKorm" is based on local probiotic strains and has numerous useful features. (Increase of nutritional value and animal production, antibacterial action, immunomodulator, protein, enzyme, vitamin provision, etc.). The State Committee of Veterinary and Livestock Development of the Republic of Uzbekistan has listed "ProBioKorm" as a probiotic feed ingredient.

Fields of application:

All aspects of animal husbandry, including livestock (livestock, cattle, sheep, goats, fish, rabbits, and poultry), are veterinary fields.

Main functional qualities:

• increases animal productivity (meat, milk), boosts animal immunity, enriches diet composition with vitamins and amino acids;
• enriches the gastrointestinal tract with desirable and active microorganisms;
• the prevention and treatment of digestive system illnesses.

Economic efficiency:

The probiotic feed additive "ProBioKorm" has no counterparts and is 50% less expensive than analogs imported from other nations. The laboratory of "Probiotics Microbiology and Biotechnology" for "ProBioKorm" created the standard Ts 03535533-011:2021, which was accepted by the State Scientific Center for Controlling the Quality and Distribution of Veterinary Medicines, Feed Additives under the State Committee for Veterinary and Livestock Development of the Republic of Uzbekistan.

ProBioKorm probiotic feed additive technological instruction number TI 03535533-011:2021 was created and authorized. VP 0996-21 is for ProBioKorm's liquid probiotic dietary supplement. The dry version of ProBioKorm probiotic feed supplement was obtained and state registered under Certificate Nos. 000996, VP 0997-21, and 000997. To ascertain and validate the safety of the probiotic feed additive, "ProBioKorm" was sent to the laboratory of the state scientific center "Control of the Quality and Circulation of veterinary drugs, feed additives" under the State Committee for Veterinary and Animal Husbandry Development.